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Expert Profile

Zintro ID: Ilan-*****
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Highly experienced leader in challenging multidisciplinary projects, from seed to working prototype.
Very wide scientific and technical background in molecular biology, protein expression/purification and analysis, material science and engineering, medical device, biosensors, electrical engineering, polymer science and analysis.
Specific expertise in the science of interfaces. Bridging between the biological and the material world.
Broad engineering background (polymers and mechanical engineering)
Track record of ~10 years of research and product development.
Broad knowledge and experience in intellectual properties matters, strategic planning, and business development

 
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CTO in clinical diagnostic startup

Research project manager at Intel

Postdoctoral fellowship at The Weizmann Institute of Science, Faculty of Chemistry.
Ph.D. in Biotechnology at The Hebrew University of Jerusalem

List of publication
Book
1. Ilan ***** and Oded Shoseyov. NanoBioTechnology: BioInspired device and materials of the future. Humana press, 2007.

Invited talks
1. Next Generation Medical Products, Systems & Services. November, 2007, Haifa, Israel.
2. Material and Nano Seminar, The Materials Science and Engineering Program and the Center for Nanoscience and Nanotechnology, January 2008, Tel Aviv University, Israel.
3. Nanotechnology Workshop, The Institute for Nanoscience and Technology, April 2008, Ben-Gurion University, Israel.
4. Biodetection Technologies Conference, June 2008, Atlanta GA.
5. Electrical engineering department guest talk, June 2008, Cambridge, UK.

Invited Reviews
1. Ilan *****, Ziv Shani and Oded Shoseyov. (2002) Modification of polysaccharides and plant cell wall by Endo-1,4-ß-glucanase (EGase) and Cellulose binding domains (CBD). Biomol. Eng. 19:*****.
2. Ilan ***** and Oded Shoseyov. (2002) Cellulose binding domains: Industrial and biotechnological application. Biotechnol. Adv. 20:*****.
3. Ilan ***** and Oded Shoseyov. (2004) Cross bridging proteins in nature and their utilization in bio- and nanotechnology. Curr. Protein Pep. Sci. 5:*****.
4. Ilan ***** Ziv Shani and Oded Shoseyov. (2006) Carbohydrate binding modules: Biochemical Properties and Novel Applications. Microbiol. Mol. Biol. Rev. 70:*****.

Conference talks
1. Ilan *****, Etai Shpigel, Amos Nussinovitch and Oded Shoseyov. Recombinant Cellulose Binding Protein-Crosslinker: A Novel Paper Composite Material. The 119th American Chemical Society National Meeting. San Francisco, USA. March 2000.
2. Ilan *****, Tzur Paldi and Oded Shoseyov. Engineering carbohydrate-binding modules for polysaccharide crosslinking. XXIst International Carbohydrate Symposium. July 2002. Cairns, Australia.
3. Andrew Machauf, Ariel Cohen, Amihood Doron, Mordehay Beraha, Boaz Weinfeld, Ilan *****. Fabrication of a sensitive field-effect device (FED) for biosensor application. IEEE International Symposium on Industrial Electronics (ISIE2007). June 2007, Spain.
4. Ariel Cohen, Amihood Doron, Andrew Machauf, Moran Horesh, Udi Virobnik, Daniela Ullien, Ilan *****. Analyte detection using field effect device with ultra thin conductive layer. Tenth World Congress on Biosensors, May 2008, Shanghai, China.
5. Eyal Capua, Roberto Cao, Carlos A. A. Eraso, Ilan *****, and Ron Naaman. Molecular controlled semiconductor devices. 2nd IEEE International Nanoelectronics Conference (IEEE NEC 2008) March 2008, Shanghai, China.

Publications
1. Etai Shpigel, Arie Goldlust, Gilat Efroni, Yossi Singer, Ilan *****, Mara Dekel and Oded Shoseyov. (2000) Expression, purification and applications of the Staphylococcal protein A fused to cellulose binding domain. Biotechnol. Appl. Biochem. 31:197–203.
2. Ilan ***** and Oded Shoseyov. (2001) Expression, refolding and indirect immobilization of horseradish peroxidase (HRP) to cellulose via a phage-selected peptide and cellulose-binding domain (CBD). J. Peptide Sci. 7:*****.
3. Ilan *****, Amos Nussinovitch, Etai Shpigel and Oded Shoseyov. (2002). Recombinant cellulose crosslinking protein: a novel paper-modification biomaterial. Cellulose 9:*****.
4. Ayelet Fishman, Ilan *****, Uri Cogan and Oded Shoseyov. (2002) Stabilization of horseradish peroxidase in aqueous-organic media by immobilization onto cellulose using a cellulose-binding domain. J. Mol. Catal. B-Enzym. 18:*****.
5. Galit Tsabary, Ziv Shani, Levava Roiz, Ilan *****, Joseph Riov and Oded Shoseyov. (2003) Abnormal “wrinkled” cell walls and retarded development of transgenic Arabidopsis thaliana plants expressing endo-1,4-ß-glucanase (cel1) antisense. Plant Mol. Biol. 15:*****.
6. Tzur Paldi, Ilan ***** and Oded Shoseyov. (2003) Starch binding domain from Aspergillus niger B1: molecular cloning, and functional characterization. Biochem. J. 372:*****.
7. Ilan *****, Gary Ward, Yitzhak Hadar, Oded Shoseyov and Carlos G. Dosoretz. (2003) Oxidation of 4-bromophenol by recombinant cellulose binding domain horseradish peroxidase fused protein immobilized to cellulose. Biotech. Boieng. 82:*****.
8. Ilan *****, Tzur Paldi, Danny Siegel and Oded Shoseyov. (2003) Cellulose Binding Domain from Clostridium cellulovorans as a Paper Modification Reagent. Nordic Pulp Paper Res. J. 18:*****.
9. Ilan *****, Tzur Paldi and Oded Shoseyov. (2004) Engineering a bifunctional protein that cross-bridge between starch and cellulose. Biomaterials 25:*****.
10. Wang-Xia Wang, Or Dgany, Sharon Grayer Wolf, Ilan *****, Rachel Algom, Yehonathan Pouny, Amnon Wolf, Ira Marton, Arie Altman and Oded Shoseyov. (2006) Aspen SP1, an exceptional thermal, protease and detergent resistant self-assembled nano-particle. Biotech. Bioeng. 95:*****. Arnon Heyman, Ilan *****, Arie Altman and Oded Shoseyov. (2007) SP1 as a novel scaffold building block for self-assembly nano-fabrication of submicron structures. NanoLetters. 7:*****.
12. Oren Shaya, Mickey Shaked, Amihood Doron, Ariel Cohen, Ilan ***** and Yossi Rosenwaks. (2008) Distinguishing between dipoles and field effects in molecular gated transistors. App. Phys. Lett. 93:*****.
13. Gil Shalev, Amihood Doron, Udi Virobnik, Ariel Cohen, Yossi Sanhedrai, and Ilan *****. (2008) Gain optimization in ISFET based sensor with fully depleted silicon-on-insulator. App. Phys. Lett. 93:*****.
14. Gil Shalev, Ezer Halpern, Amihood Doron, Ariel Cohen, Yossi Rosenwaks and Ilan *****. Surface chemical modification induces nanometer scale electron confinement in field effect device. J. Chem. Phys. 131: *****.
15. Oren Shaya, Mickey Shaked, Yulia Usherenko, Ezer Halperin, Gil Shalev Amihood Doron, Ilan ***** and Yossi Rosenwaks. (2009) Tracing the mechanism of molecular gated transistors. J. Phys. Chem. C 113: 6163–6168.
16. Gil Shalev, Ariel Cohen, Amihood Doron, Andrew Machauf, Moran Horesh, Udi Virobnik, Daniela Ullien and Ilan *****. (2009) Standard CMOS Fabrication of a Sensitive Fully Depleted Electrolyte-Insulator-Semiconductor Field Effect Transistor for Biosensor Application. Sensor 9: *****.
17 Eliezer Halpern, Bassam Khamaisi, Oren Shaya, Gil Shalev, Ilan *****, and Yossi Rosenwaks. (2009) Electrostatic properties of silan monoleyers in an electrolytic envinronment. J. Phys. Chem.113: *****.

Proceedings
1. Oded Shoseyov, Ilan *****, Ziv Shani, and Shawn Mansfield. (2003) Modulation of wood fibers and paper by cellulose binding domains (CBDs). In: Application of enzymes to lignocellulosics. (Shawn D. Mansfield and John N. Saddler, Ed.). ACS Symposium series 855:*****.

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