For the past 5 years, I have been Head of Analysis for a SME focused on biomedicine, designing and conducting research projects, and developing methods and software, with the goal of finding the genetic roots of diseases.

Previously, I worked at US and UK universities on Statistical Genetics analysis.

B.Sc. in Neural Sciences, Brown University, Providence, RI, USA.
M.A. in Behavioral Genetics, University of Colorado, Boulder, CO, USA.
Ph.D. in Behavioral Genetics, University of Colorado, Boulder, CO, USA.

List of publications:


1. Genetic association of complement receptor 1 polymorphism rs***** in Alzheimer's disease.
Antúnez C, Boada M, López-Arrieta J, Moreno-Rey C, Hernández I, Marín J, Gayán J; Alzheimer's Disease Neuroimaging Initiative, González-Pérez A, Real LM, Alegret M, Tárraga L, Ramírez-Lorca R, Ruiz A.
Alzheimers Dement. 2011 Jul;7(4):e*****.
PMID: *****. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
Antúnez C, Boada M, González-Pérez A, Gayán J, Ramírez-Lorca R, Marín J, Hernández I, Moreno-Rey C, Morón FJ, López-Arrieta J, Mauleón A, Rosende-Roca M, Noguera-Perea F, Legaz-García A, Vivancos-Moreau L, Velasco J, Carrasco JM, Alegret M, Antequera-Torres M, Manzanares S, Romo A, Blanca I, Ruiz S, Espinosa A, Castaño S, García B, Martínez-Herrada B, Vinyes G, Lafuente A, Becker JT, Galán JJ, Serrano-Ríos M; Alzheimer's Disease Neuroimaging Initiative, Vázquez E, Tárraga L, Sáez ME, López OL, Real LM, Ruiz A.
Genome Med. 2011 May 31;3(5):33.
PMID: *****. The MTHFD1L gene rs***** marker is not associated with Alzheimer's disease in a sample of the Spanish population.
Ramírez-Lorca R, Boada M, Antúnez C, López-Arrieta J, Moreno-Rey C, Hernández I, Marín J, Gayán J, González-Pérez A, Alegret M, Tárraga L, Real LM, Ruiz A.
J Alzheimers Dis. 2011;25(1):*****.
PMID: *****. WWOX gene is associated with HDL cholesterol and triglyceride levels.
Sáez ME, González-Pérez A, Martínez-Larrad MT, Gayán J, Real LM, Serrano-Ríos M, Ruiz A.
BMC Med Genet. 2010 Oct 14;11:148.
PMID: *****. Estrogen receptor alpha gene variants are associated with Alzheimer's disease.
Boada M, Antunez C, López-Arrieta J, Caruz A, Moreno-Rey C, Ramírez-Lorca R, Morón FJ, Hernández I, Mauleón A, Rosende-Roca M, Martínez-Lage P, Marín J, Tárraga L, Alegret M, Pedrajas JR, Urda N, Royo JL, Saez ME, Gayán J, González-Pérez A, Real LM, Ruiz A, Galán JJ.
Neurobiol Aging. 2010 Jul 29. [Epub ahead of print]
PMID: *****. "Does replication groups scoring reduce false positive rate in SNP interaction discovery? Response".
Gayán J, González-Pérez A, Ruiz A.
BMC Genomics. 2010 Jun 24;11:403.
PMID: *****. Genetic structure of the Spanish population.
Gayán J, Galan JJ, González-Pérez A, Sáez ME, Martínez-Larrad MT, Zabena C, Rivero MC, Salinas A, Ramírez-Lorca R, Morón FJ, Royo JL, Moreno-Rey C, Velasco J, Carrasco JM, Molero E, Ochoa C, Ochoa MD, Gutiérrez M, Reina M, Pascual R, Romo-Astorga A, Susillo-González JL, Vázquez E, Real LM, Ruiz A, Serrano-Ríos M.
BMC Genomics. 2010 May 25;11:326.
PMID: *****. An entropy test for single-locus genetic association analysis.
Ruiz-Marín M, Matilla-García M, Cordoba JA, Susillo-González JL, Romo-Astorga A, González-Pérez A, Ruiz A, Gayán J.
BMC Genet. 2010 Mar 23;11:19.
PMID: *****. Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment.
Rice ML, Smith SD, Gayán J.
J Neurodev Disord. 2009 Dec;1(4):*****. Epub 2009 Aug 26.
PMID: *****. GOLPH2 gene markers are not associated with Alzheimer's disease in a sample of the Spanish population.
Antúnez C, Boada M, López-Arrieta J, Ramirez-Lorca R, Hernández I, Marín J, Martínez-Lage P, González-Pérez A, Jorge Galan J, Gayán J, Real LM, Ruiz A.
J Alzheimers Dis. 2009;18(4):*****.
PMID: *****. GAB2 gene does not modify the risk of Alzheimer's disease in Spanish APOE 4 carriers.
Ramirez-Lorca R, Boada M, Saez ME, Hernandez I, Mauleon A, Rosende-Roca M, Martinez-Lage P, Gutierrez M, Real LM, Lopez-Arrieta J, ***** J, Antunez C, Gonzalez-Perez A, Tarraga L, Ruiz A.
J Nutr Health Aging. 2009 Mar;13(3):*****.
PMID: *****. Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease.
González-Pérez A, Gayán J, Marín J, Galán JJ, Sáez ME, Real LM, Antúnez C, Ruiz A.
Neurogenetics. 2009 Jul;10(3):*****. Epub 2009 Jan 21.
PMID: *****. Repeat instability in the ***** CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.
Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR; International-Venezuela Collaborative Research Group.
Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):*****.
PMID: *****. A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis.
Gayán J, González-Pérez A, Bermudo F, Sáez ME, Royo JL, Quintas A, Galan JJ, Morón FJ, Ramirez-Lorca R, Real LM, Ruiz A.
BMC Genomics. 2008 Jul 31;9:360.
PMID: *****. Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.
Gayán J, Brocklebank D, Andresen JM, Alkorta-Aranburu G; US-Venezuela Collaborative Research Group, Zameel Cader M, Roberts SA, Cherny SS, Wexler NS, Cardon LR, Housman DE.
Genet Epidemiol. 2008 Jul;32(5):*****.
PMID: *****. The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.
Andresen JM, Gayán J, Djoussé L, Roberts S, Brocklebank D, Cherny SS; US-Venezuela Collaborative Research Group; HD MAPS Collaborative Research Group, Cardon LR, Gusella JF, MacDonald ME, Myers RH, Housman DE, Wexler NS.
Ann Hum Genet. 2007 May;71(Pt 3):*****. Epub 2006 Dec 19.
PMID: *****. Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds.
Andresen JM, Gayán J, Cherny SS, Brocklebank D, Alkorta-Aranburu G, Addis EA; US-Venezuela Collaborative Research Group, Cardon LR, Housman DE, Wexler NS.
J Med Genet. 2007 Jan;44(1):*****. Epub 2006 Oct 3.
PMID: *****. Bivariate linkage scan for reading disability and attention-deficit/hyperactivity disorder localizes pleiotropic loci.
Gayán J, Willcutt EG, Fisher SE, Francks C, Cardon LR, Olson RK, Pennington BF, Smith SD, Monaco AP, DeFries JC.
J Child Psychol Psychiatry. 2005 Oct;46(10):*****.
PMID: *****. Reading disability and chromosome 6p21.3: evaluation of MOG as a candidate gene.
Smith SD, Kelley PM, Askew JW, Hoover DM, Deffenbacher KE, Gayán J, Brower AM, Olson RK.
J Learn Disabil. 2001 Nov-Dec;34(6):*****.
PMID: *****. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.
Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O'Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS Jr, Landwehrmeyer B; U.S.-Venezuela Collaborative Research Project.
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):*****. Epub 2004 Mar 1.
PMID: *****. Genetic and environmental influences on individual differences in printed word recognition.
Gayán J, Olson RK.
J Exp Child Psychol. 2003 Feb;84(2):*****.
PMID: *****. Differential genetic etiology of reading component processes as a function of IQ.
Knopik VS, Smith SD, Cardon L, Pennington B, ***** J, Olson RK, DeFries JC.
Behav Genet. 2002 May;32(3):*****.
PMID: *****. Evidence for linkage and association with reading disability on 6p21.3-22.
Kaplan DE, Gayán J, Ahn J, Won TW, Pauls D, Olson RK, DeFries JC, Wood F, Pennington BF, Page GP, Smith SD, Gruen JR.
Am J Hum Genet. 2002 May;70(5):*****. Epub 2002 Apr 10.
PMID: *****. Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder.
Willcutt EG, Pennington BF, Smith SD, Cardon LR, Gayán J, Knopik VS, Olson RK, DeFries JC.
Am J Med Genet. 2002 Apr 8;114(3):*****.
PMID: *****. Genetic and environmental influences on orthographic and phonological skills in children with reading disabilities.
Gayán J, Olson RK.
Dev Neuropsychol. 2001;20(2):*****.
PMID: *****. Etiology of reading difficulties and rapid naming: the Colorado Twin Study of Reading Disability.
Davis CJ, Gayán J, Knopik VS, Smith SD, Cardon LR, Pennington BF, Olson RK, DeFries JC.
Behav Genet. 2001 Nov;31(6):*****.
PMID: *****. Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia.
Fisher SE, Francks C, Marlow AJ, MacPhie IL, Newbury DF, Cardon LR, Ishikawa-Brush Y, Richardson AJ, Talcott JB, Gayán J, Olson RK, Pennington BF, Smith SD, DeFries JC, Stein JF, Monaco AP.
Nat Genet. 2002 Jan;30(1):*****. Epub 2001 Dec 17.
PMID: *****. Parents' and teachers' ratings of problem behaviours in children: genetic and contrast effects.
Kuntsi J, Gayán J, Stevenson J.
Twin Res. 2000 Dec;3(4):*****.
PMID: *****. Reading disability: evidence for a genetic etiology.
Gayán J, Olson RK.
Eur Child Adolesc Psychiatry. 1999;8 Suppl 3:52-5.
PMID: *****. Varieties of developmental reading disorder: genetic and environmental influences.
Castles A, Datta H, ***** J, Olson RK.
J Exp Child Psychol. 1999 Feb;72(2):*****.
PMID: *****. Quantitative-trait locus for specific language and reading deficits on chromosome 6p.
Gayán J, Smith SD, Cherny SS, Cardon LR, Fulker DW, Brower AM, Olson RK, Pennington BF, DeFries JC.
Am J Hum Genet. 1999 Jan;64(1):*****.
PMID: *****