Expert Profile
I am a research scientist speci ***** zing in the area of immunology, particularly T cell & B cell biology. I also have extensive background in immune responses as they pertain to various infectious diseases such as HIV, influenza, malaria & TB. Furthermore, I have a strong background in immunotherapy/vaccine development.
The University of Chicago, Department of Medicine/Section of Rheumatology, POSTDOCTORAL SCHOLAR, 2009-present. •Conducted laboratory research investigating B cell immune responses to vaccination in humans & non-human primates
•Produced & analyzed antigen-specific fully human monoclonal antibodies
DENTSPLY PHARMACEUTICAL, MICROBIOLOGIST, *****.
•Helped v*****date sterility of a start-up facility that manufactured a sterile injectable human drug in a clean room environment
•Developed, v*****dated, implemented, & documented methods according to FDA GLP & GMP guidelines
THE DOW CHEMICAL COMPANY-BIOCIDES, R&D Tech (Microbiology & Chemistry), *****.
•Tested anti-microbial agents against variety of bacteria & fungi in compounds such as Personal Care Products, Building Materials, Water, Paints and Coatings
•Helped formulate chemical anti-microbial agents (biocides)
UNIVERSITY OF CHICAGO, MOLECULAR BIOLOGY RESEARCH ASSISTANT, *****.
•Conducted laboratory research investigating the gene(s) responsible for the "extra eye" mutation in fruit flies
INTERNATIONAL CHILDREN’S CENTER, LIFE SKILLS COUNSELOR / SCIENCE TEACHER, *****.
•Counseled & taught science classes to juvenile immigrants
DOCTOR OF PHILOSOPHY, DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, University of Illinois at Chicago, College of Medicine, Center for Primate Biomedical Research, *****
Dissertation: Investigating microbial antigen-mediated T cell responses in healthy & AIDS-virus infected non-human primates
BACHELOR OF SCIENCE IN BIOLOGY, Loyola University Chicago, *****
1) J. Wrammert, D. Koutsonanos, G.M. Li,*****puganti, J. Sui, M. Morrissey, M. McCausland, I. Skountzou, M. Hornig, W. Lipkin, A. Mehta, B. Razavi, C. Del Rio, N.Y. Zheng, J.H. Lee, M. Huang, Z. *****, K. Kaur, S. Andrews, R. Amara, Y. Wang, S. Das, C.D. O'Donnell, J. Yewdell, K. Subbarao, W.A. Marasco, M.J. Mulligan,*****pans, R. Ahmed, and P.C. Wilson. 2011. Broadly cross-reactive antibodies dominate the acute B cell response against pandemic 2009 H1N1 influenza virus infection in humans. J. Ex. Med. 208(1):*****.
2) *****, Z., Yan, L., Plagman, N., Reichenberg, A., Hintz, M., Jomaa, H., Villinger, F., Chen, Z.W. 2009. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection confers immunological benefits. J Immunol 183:*****.
3) Huang, D., Chen, C.Y., *****, Z., Shao, L., Shen, L., Lockman, H.A., Barnewall, R.E., Sabourin, C., Eestep, J., Reichenberg, A., Hintz, M., Jomaa, H., Wang, R., Chen, Z.W. 2009. Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plague lesions. Proc Natl Acad Sci U S A 106(18):*****.
4) Chen, Y., L. Shao, Z. *****, J. Cai, and Z. W. Chen. 2008. NSOM/QD-based nanoscale immune-fluorescence imaging of antigen-specific T cell receptor responses during an in vivo clonal V{gamma}2V{delta}2 T cell expansion. Blood 111:*****.
5) *****, Z., L. Shao, L. Halliday, A. Reichenberg, M. Hintz, H. Jomaa, and Z. W. Chen. 2007. Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques. J Immunol 179:*****.