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Recent Bioanalytical Inquiries

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Bioanalytical Method Development And Validation

I am going to develop a bioanalytical method usinh artificial aqueous humor(nacl, kcl, cacl2, nahco3, na-lactate, na-ascorbate, glucose, urea, and albumin),so should i need to perform extraction procedure(solid phase extraction etc.) for sample preparation and internaĺ standard??please help me as early as possiboe,i am really in need!!

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    Norm |Process Analytical Consultant

    Assuming no ***** your list of aqueous humor components, ***** the individual compo...

    1.7 Hours Later
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    Michael |Senior Principal Consultant

    I am a Senior SME for Bioanalytical for MD, MV, MT and SA) and have written the Book entitled "Regul...

    1.8 Hours Later
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    JR |Zintro Expert

    Reference book: Title: Comprehensive sampling and sample preparation : analytical techniques for sci...

    2.8 Hours Later
+10 Other Responses
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Pharmacology

Senior scientist/associate director – pharmacology, this an employment opportunity in california, usa. Responsibilities this new role will interact with senior management and serve as the company-wide resource in the areas of pharmacokinetics and bioanalysis. The successful candidate will: -participate in the design, implementation, analysis and reporting of preclinical studies generating pk or pk/pd data -conduct modeling/simulation of pk and pk/pd data which seek to predict human efficacious dose, optimize dosing regimen, describe exposure-response and model probody activity -provide pk(/pd) guidance in development of nonclinical and clinical study protocols -select and manage outside labs providing contract pk or bioanalytical services -oversee method development/validation and innovate as necessary to meet program needs for probody or pdc bioanalysis -work closely with project scientists, toxicologists, clinical leads and multi-disciplinary teams to develop an integrated approach to probody bioanalysis and pk assessment -contribute to the writing of study reports and organization of pk data in support of regulatory submissions requirements: -phd, or pharm.D. In pharmaceutical sciences or a related field -7+ years relevant industry experience supporting both preclinical activities and clinical trials; experience must include therapeutic antibodies and/or antibody-drug conjugates -proven proficiency in the use of pk and pk/pd data analysis software, compartmental & non-compartmental data analysis as well as modeling and simulation. -state-of-the-art knowledge of large molecule bioanalysis including pk, pd and ada assays for antibodies and adcs -the candidate should have extensive experience in working with multidisciplinary teams, competency in developing strategy and guiding pk-based drug discovery/development decisions

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    Endre |CEO, CSO

    Dear Sir (Madam), I am interested in this position. I have beed the head of pharmacology at Sanofi ...

    18.7 Hours Later
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    Steven |Zintro Expert

    Dear Human Resources, I am quite interested in the available Senior Scientist / *****ctor,...

    5 Days Later
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    Anthony |Zintro Expert

    Yes, I wish to apply for this position of Senior Scientist/Assoc Dir Pharmacology ...

    11.8 Days Later
+9 Other Responses
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Clinical Laboratory Operations

Laboratory director of operations boston, ma the laboratory services provide for a diverse range of simple to highly complex routine and esoteric assays supported by a broad base of technologies including ria, elisa, cell based assays, colorimetric assays, pcr, cell culture, hplc and spectroscopy. In this role you will be responsible for all activities in the laboratory including but not limited to: - setting direction and allocating resources to assure that the laboratory meets the production requirements while maintaining a quality level that meets regulatory requirements. - assuring that all facets of people, equipment, documentation and procedures are compliant to all required regulatory agencies. - recruiting, training, reviewing and mentoring lab employees - working with the laboratory director, senior management, clinical r&d, quality assurance, sales, finance and other departments as required. - investigating employee incidents and accidents, communicating these problems to the laboratory director and senior management as required. - taking an active role in dealing with employee suggestions, complaints and grievances. - coordinating with lab supervisor(s) in setting performance standards for clinical laboratory personnel. - working with staff and management to plan and formulate clinical goals and objectives. - ensuring completion of deliverables and adherence to timelines; track milestones and timelines across projects and institute necessary work flow, personnel and financial resource allocations, making alterations when necessary to meet expectations of clients - analyzing and resolving issues that have the potential to jeopardize performance and/or ability to meet agreed upon deliverables; analyze financial and operational reports. - analyzing trends, developing and maintaining a program for organizational learning and sharing of experiences, internally and externally. - developing programs to improve laboratory efficiency and reduce costs. - managing laboratory documentation - maintaining familiarity with the laboratory information system (lis) - participates as an active member of the clinical laboratory staff to improve the overall efficiency of the laboratory - participates in planning sessions and coordinates training of technologists with the technical supervisor to improve the performance of the clinical laboratory. Qualifications position requires a phd and national certification (ascp) as a medical technologist or clinical laboratory scientist. Minimum of 5-7 years as a laboratory manager/director managing a cro central lab or a bioanalytical lab performing highly complex assays. Experience with the following technologies elisa, pcr, and/or hplc. Strong computer skills and the ability to work in a flexible environment and adapt easily to change in direction.

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    Rosalynn |Consultant

    Providing ***** scientific leadership in areas of CLIA *****ations along with pro...

    1.2 Hours Later
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    John |President

    I am interested in discussing this position further. I am a board certified clinical chemist and I h...

    1.2 Hours Later
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    Ojingwa |Research Associate, Manufacturer's repre

    Hello I am very interested in this position please checkout my linked in profile at ojingwa Ginny Gu...

    47.9 Days Later
+5 Other Responses
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E.coli Expression System

Experience in e.Coli expressed protein purification from inclusion bodies is essential. Experience in cytokines specially interferon beta 1-b purification and formulation process development is desired.

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    Sam |Director of Molecular Biology

    Sir/Madam, I have cloned, expressed, and purified approximately 75 proteins. Inclusion bodies & the...

    1.8 Hours Later
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    ALOKESH |SCIENTIST

    i cannot see your phone number maybe you need to get the premium access...

    18.6 Hours Later
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    Debasish |Associate Professor

    I am an expert on protein expression, purification, I am available for phone consultation....

    1.1 Days Later
+5 Other Responses
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Bioanalytical Testing

Bioanalytical testing - indian market. Looking for an expert who can share the insights on the current dynamics of the indian market for bioanalytical testing in terms of technology, regulations and the cost saving opportunities.

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    Pankaj |Research Biologist

    With due regards and reference regards to bioanalytical query. I wish to ***** myself Pankaj Jo...

    1.6 Hours Later
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    Shyam |VP of Finance

    Having worked with Cliantha systems on a project (Bioanalytical testing lab in India) I can assist w...

    12.6 Hours Later
+3 Other Responses
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Analytical Testing Services

Seeking expertise in bioanalytical & analytical services. Require understanding on market size, growth, outsourcing patterns, and best practices in terms of sourcing, engagement and pricing models.

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    Shyam |VP of Finance

    I have deep expertise in analytical testing service procurement and can assist...

    1.8 Hours Later
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    Shakil |Chief Scientific Officer

    I will be able help. We have lab where all kind of bioanalytical and analytical testing is performed...

    4.5 Hours Later
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    Mark |Project Director

    I work as a project manager and consultant in this field. A large part of my work is completed by s...

    5.9 Hours Later
+16 Other Responses
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Capillary Electrophoresis

Primeradx is seeking a system development chemist to study various aspects of capillary electrophoresis and pcr. Primary need is for an experienced professional who can execute experiments that characterize and improve system protocols: o characterize and improve capillary electrophoresis performance o optimize polyacrylimide gel and silicon capillary surface chemistry o characterize carryover contamination o execute experiments with dyes and injection in order to improve the qc measurements related to optical sensitivity. Primeradx is dedicated to the emerging field of molecular diagnostics. The company has developed a multiplexed, quantitative/qualitatitive and cost effective assay platform using its proprietary star technology implemented on the iceplex instrument platform. Star combines pcr with the ability to multiplex up to 60 targets in a single sample. The company’s initial products are for infectious disease management. Primeradx plans to extend its focus into oncology to support cancer therapy management through diagnostic, prognostic, staging and therapeutic monitoring.

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    Chu |Director, Analytical & Formulation Devel

    I have extensive experience in CE (chiral small molecule, proteins (CZE, iCIEF, CGE) and nanoparticl...

    3.1 Days Later
+1 Other Responses
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Global Warming

Expert on triatomic molecule co2 and quantized energy absorption across infra red spectrum; effect of above on saturation.

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    Michael |Scientist innovator

    I have a background in infrared physics, My major was in physics. This area is of intense interest t...

    8.4 Hours Later
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    E.V.S. |Consultant & Advisor

    I have an expertise in ***** global warming, especially through terrestrial measures such as...

    10.1 Hours Later
+2 Other Responses
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Bioanalytical Method Development And Validation

We are a small start-up near boulder, co looking for a lab that can analyze plasma pk samples for metformin concentration. In addition, need a lab that can analyze metformin concentrations in human stool samples. Thank you, laurie

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    Duane |President

    As a trained bioanalytical chemistry (BAC) expert, I have the necessary expertise and experience to ...

    3.9 Hours Later
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    Prasad |Principal

    Dear Laurie: We can take care of the lab analysis part which include **********, Per sa...

    1.2 Days Later
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    Pankaj |Research Officer

    Dear Laurie, Fortis Clinical research Limited (FCRL), India has been completed multiple pharmacokine...

    1.7 Days Later
+8 Other Responses
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Bioanalytical Sciences, Drug Metabolism,

We are looking for experts (one in human drug metabolism and one in animal and human toxicology) to provide summary reviews of the extant literature on two active ingredients, which will be disclosed after a cda is signed. These are oral active agents, with one in rx use for decades and another for food use for a number of years. There is considerable published literature on each active. The review would inform the project team about possible pharm/tox and metabolic studies needed in support of a 505(b)(2) application, as well as the summary write-up for the ind application. Respondents to this search should have hands-on experience in rx drug development and an understanding of fda requirements for drug approval.

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    Jeffrey |President and Managing Director

    I am an MD/PhD basic and clinical pharmacologist with more than 30 years of drug development experie...

    27 Minutes Later
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    May D. |Director

    I am very interested in this project. I am a recently retired bioanalytical, DM/PK R&D scientist wit...

    30 Minutes Later
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    Michael |Principal

    I would be happy to discuss your needs. I have extensive experience in toxicology and ADME studies,...

    2.5 Hours Later
+14 Other Responses
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Protein-ligand Docking

Hello, i am looking for an expert in protein-ligand docking to assist me with a project. I wish to dock two ligands to the delta, mu and kappa opioid receptors (the crystal structures of these receptors are known and are available on rcsb pdb). I have experimental ic50 values for each of the 2 well-known ligands (structural analogues) interacting with with each of the 3 opioid receptors. I would like an expert to help to help explain why these 2 structural analogues behave quite differently when docked to the opioid receptors (greater than 10-fold differences in ic50 values). I can provide the experimental ic50 data. High quality color figures (such as in crystal structure of the âµ-opioid receptor bound to a morphinan antagonist nature. 2012 mar 21;485(7398):321-6) are needed, along with a figure which clearly identifies the key amino acid (or water) interactions. Any additional information to help explain the differences in potency (e.G. Energetics, electrostatics etc..) would also be great. An overall showing how the 2 ligands interact when docked to the 3 proteins would be good too. A time and price estimate would be appreciated. Thank you.

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    Antonio |Staff Scientist

    I have a great deal of expertise in this area. Please contact me here if you are interested in talk...

    1.2 Hours Later
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    Nilesh |Senior Scientist

    Hi I can do this job to your ***** total cost of job will be around five hundred us dolla...

    4 Hours Later
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    Esben |Consultant

    Hi, I want to ask from where you have the IC50 values, and how they were determined? Is it cor...

    5.1 Hours Later
+13 Other Responses
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Monoclonal Antibody

Looking to develop a should cost model for production of monoclonal antibodies using stainless steel and disposable bioreactors -€“ looking to understand the productivity difference in stainless steel bioreactor vs. Disposable bioreactors - contribution of capital charges, raw material cost, consumables cost, labor cost, and other charges in total cogs - operating profit margin and net profit margins for cmos and biologic companies

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    sourabh |Research Scientist

    Hi, I have done this sort of analysis earlier. Could you please provide more context on the reason f...

    3.1 Hours Later
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    Pirouz |Director and assistant professor

    I can help as I hsve been the director of a hybridoma core faciloty. Need more info to estimaye how ...

    6.9 Hours Later
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    Daniel |Account Manager

    Hello, Utkarsh. I would be happy to speak with you about your project involving MAB production. I ...

    5.1 Days Later
+4 Other Responses
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