Scientist Molecular Biology/expression
-support antibody cloning, antibody engineering and therapeutic candidate identification
-design and express reagent proteins
-plan, execute and troubleshoot experiments
-examine data and prepare reports
-maintain laboratory including equipment maintenance and ordering of supplies
-master’s degree or bachelor’s degree with 8-10 years of directly related experience
-ph.D. Degree with 0-3 relevant postdoctoral experience preferred
-strong publication record and demonstrated expertise in protein expression and antibody engineering
-highly skilled in molecular biology/dna technology techniques
-extensive experience in v-gene cloning from hybridomas
-experience in restriction enzyme dependent and independent (seamless) cloning
-expertise in antibody engineering, bispecific antibody design and antibody humanization
-knowledge in protein expression in multiple systems and/or purification, a plus
-excellent team work and collaboration skills
-demonstrated ability to work in a cross-functional environment
-outstanding written and verbal communication skills
-independent, innovative and creative thinker
-detail oriented with strong organizational and time management skills
-must be able to work in a fast paced, changing environment with demonstrated ability to manage multiple competing responsibilities with a high degree of self-motivation.+29 Other Responses
This is a full time employment opportunity for a cell biology scientist in the san francisco area.
The successful candidate will play an integral role as a key team member of a group focused supporting our therapeutic candidate discovery efforts as well as on the development and characterization of high productivity manufacturing cho cell lines.
The successful candidate will be highly skilled in cell biology and state-of-art recombinant protein expression technologies. Extensive experience in high titer expression of proteins in mammalian cell culture systems is required. Additional expertise in transfection and selection of stable cell lines, single cell cloning, and evaluation of clonal cell lines for productivity and product quality is highly desired. In addition, knowledge and background in protein biosynthesis and trafficking is a plus.
-generate recombinant proteins and antibodies to support discovery research
-troubleshoot/optimize expression of difficult to express recombinant proteins
-perform activities associated with production/manufacturing cell line generation and optimization; including transfection, selection, single cell cloning, high throughput screening, cell banking, etc.
-may support early stage process development efforts
-analyze, interpret and effectively present data at group and team meetings, work collaboratively and cross-functionally to achieve common goals.
-may supervise and mentor scientific staff
-highly skilled in cell biology and aseptic cell culture of mammalian cells
-extensive experience in expressing proteins in transient expression and stable systems and knowledge/skills in molecular biology and protein biochemistry are highly desired
-preferred qualification: ph.D. Degree with 1-3 years of relevant postdoctoral experience.
-minimum qualification: master’s degree or bachelor’s degree with 8-10 years of direct relevant experience.
-strong publication record and demonstrated expertise in cell biology, protein expression and related fields.+57 Other Responses
Cell biologist needed to write sop and scope of work for an raw type cell assay. Involves human hsp10, interaction with tlr's and purity of protein samples such as svt2cdi and svt2a. Prefer west coast location.Possible monitoring of assays by acro included.+7 Other Responses