The minor actinides are the actinide elements in used nuclear fuel other than uranium and plutonium, which are termed the major actinides. The minor actinides include neptunium, americium, curium, berkelium, californium, einsteinium, and fermium. The most important isotopes in spent nuclear fuel are neptunium-237, americium-241, americium-243, curium-242 through -248, and californium-249 through -252. Plutonium and the minor actinides will be responsible for the bulk of the radiotoxicity and heat generation of used nuclear fuel in the medium term (300 to 20,000 years in the future). There are no fission products with halflife in this range.