We are looking for an analytical assay qualification expert in the development of pharmaceutical and biotechnology processes to meet we acquire, assess, or rapidly and economically develop process technology or production capabilities needed. The expert would able to guide work for analytic assay qualification used for the clinical and commercial manufacture of therapeutic proteins. This expert will plan, provide protocols and advices in support of analytical assays qualification, include development of mass spectrometric techniques, chromatographic and electrophoretic methods, in vitro potency assays to support process development, quality control and physicochemical characterization of therapeutic antibodies and antibody drug conjugates. In addition, the expert knowledge in interim reference standard, glp toxicology (in vivo portion), lot release (qa & qc) and various regulatory submissions including ind, bla, impd, etc. This expert will also be expected to direct the technical activities of junior scientists. A hands-on, laboratory-based effort will be desirable.
Areas of expertise:
seeking experts with knowledge of analytical assay qualification; analytical assay; biotechnology process; therapeutic proteins; protein synthesis; antibodies; therapeutic antibodies; antibody; biochemist; biochemistry+12 Other Responses
Want to know about different techniques and about the sequencing.+9 Other Responses
E.coli Expression System
Experience in e.Coli expressed protein purification from inclusion bodies is essential. Experience in cytokines specially interferon beta 1-b purification and formulation process development is desired.+5 Other Responses
I am looking for a comprehensive computer platform for protein modeling and structure-guided protein engineering. A computer platform that can develop high quality models of the protein structures and its complexes with other proteins; can optimize conformations and provide insight into the dynamic nature of the protein structure from point of therapeutic or receptor interaction; allows to determine the structural characteristics of the protein and targets in the context of energy functions.+9 Other Responses
Protein Analytics And Characterization
This is a 12 month contract opportunity in california: post-doctoral fellow/scientist ii analytical development - protein analytics and characterization
as a member of the analytical development team, this position will support early to late stage
development focused on protein analytics and characterization. The successful candidate may
develop, transfer, and validate protein analytical methods for drug substance and drug product
release, stability and characterization.
conduct bench activities for protein analytical characterization of new drug candidates.
Optimize, and qualify test methods for assigned projects.
May assist with review technical documents including analytical method development reports,
method validation protocols and reports, standard operating procedures in compliance with
Actively support testing of new drug candidates at various stages of development.
Participate in technical transfer of assays to qc and process development and contract
laboratories in a cgmp or glp environment, if appropriate.
phd in relevant field with minimum of 0 to 2 years’ related academic experience in analytical
development for the post doc i; the sr post doc will have 2 to 4 years’ of post-doctoral
Experience with analytical techniques including but not limited to hplc, ce, spectrophotometric
assays, sds-page, elisa and light scattering is desirable.
Knowledge of statistical data analysis preferred.
Some experience with analytical, technical writing, communication and data management skills
Knowledge and/or understanding of working in a glp/gmp highly desirable.
Contact us here on zintro for further details.+9 Other Responses
Poultry Feed Formulation
We are looking for professionals that would be able
to assist us in the formulation of protein for animal feed using feathers, blood and animal waste.+10 Other Responses
Analytical Assay Qualification
We are looking for an analytical assay qualification expert in the development of pharmaceutical and biotechnology processes to meet we acquire, assess, or rapidly and economically develop process technology or production capabilities needed. The expert would able to guide work for analytic assay qualification used for the clinical and commercial manufacture of therapeutic proteins. This expert will plan, provide protocols and advices in support of analytical assays qualification, include development of mass spectrometric techniques, chromatographic and electrophoretic methods, in vitro potency assays to support process development, quality control and physicochemical characterization of therapeutic antibodies and antibody drug conjugates. In addition, the expert knowledge in interim reference standard, glp toxicology (in vivo portion), lot release (qa & qc) and various regulatory submissions including ind, bla, impd, etc. This expert will also be expected to direct the technical activities of junior scientists. A hands-on, laboratory-based effort will be desirable.+19 Other Responses
We are a membrane system manufacturer that has been approached to design and build a system using microfiltration, ultrafiltration and reverse osmosis to concentrate a protein in their process. We would need someone to for design review ,and technical support during commissioning looking for an expert who has a background in:
1) knowledge in the protein extraction process
2) understanding of protein as a food additives
3) understanding membrane based technology
please respond with your resume and a summary of your qualifications.+9 Other Responses
i am looking for an expert in protein-ligand docking to assist me with a project. I wish to dock two ligands to the delta, mu and kappa opioid receptors (the crystal structures of these receptors are known and are available on rcsb pdb). I have experimental ic50 values for each of the 2 well-known ligands (structural analogues) interacting with with each of the 3 opioid receptors. I would like an expert to help to help explain why these 2 structural analogues behave quite differently when docked to the opioid receptors (greater than 10-fold differences in ic50 values). I can provide the experimental ic50 data. High quality color figures (such as in crystal structure of the âµ-opioid receptor bound to a morphinan antagonist nature. 2012 mar 21;485(7398):321-6) are needed, along with a figure which clearly identifies the key amino acid (or water) interactions. Any additional information to help explain the differences in potency (e.G. Energetics, electrostatics etc..) would also be great. An overall showing how the 2 ligands interact when docked to the 3 proteins would be good too.
A time and price estimate would be appreciated.
Thank you.+13 Other Responses
High Throughput Docking
I am interested in having high-throughput protein docking screening performed on a crystal structure of interest (from the pdb website). I am seeking someone with the expertise and computational tools to allow for screening of very large data-sets (millions of compounds) through the crystal structure. Analysis would include identification of key molecular scaffolds/functional groups that are involved (or not involved) in docking. A method, docking score, statistics, graphs and illustration of structures will need to be provided as well as overall conclusions about the physicochemical properties of molecules/scaffolds that dock with the protein.
A time and cost estimate would be helpful. Thank you.+26 Other Responses
my name is santhosh and i am working as an independent medical device consultant. One of my clients is a manufacturer of collagen and is interested in expanding the collagen sales in different parts of the world, could you please guide me on this issue. Service charges can be discussed.
santhosh.+9 Other Responses
Protein Powder Formulation
I am looking for an expert to help me with the formulation and manufacturing requirements for a protein powder.
It has to be three flavors vanilla, chocolate and strawberry, benchmark would be dymatize iso 100. It needs to be low to no carb, low to no fat and low to no cholesterol. I would rather use camel milk whey than cow milk whey if it is cost effective.
The issue of denatured proteins need to be addressed as well as the issue with the metals that some say are present in the milk.
I am also looking for assistance in setting up the plant. This would consist of what machinery i need, what certifications and other such matters.
akram+14 Other Responses